Search results for " sentinel lymph node biopsy"

showing 8 items of 8 documents

Sentinel-node biopsy in early stage ovarian cancer: a prospective multicentre study (SELLY)

2019

BackgroundSystematic para-aortic and bilateral pelvic lymphadenectomy is included in the standard comprehensive surgical staging in presumed early epithelial ovarian cancer. No prospective randomized evidence suggests it has potential therapeutic value, and related morbidity is not negligible.Primary Objective(s)To assess sensitivity, safety, and feasibility of the sentinel lymph node technique in identifying the presence of lymph node metastases in patients with early stage epithelial ovarian cancer.Study HypothesisSentinel lymph node detection with indocyanine green can accurately predict nodal status in a cohort of women with early stage epithelial ovarian cancer.Trial DesignThe SELLY tr…

medicine.medical_specialtyearly ovarian cancermedicine.medical_treatmentearly ovarian cancer; indocyanine green (ICG); laparoscopy; lymphadenectomy; minimally-invasive surgery; sentinel node; Carcinoma Ovarian Epithelial; Cohort Studies; Female; Humans; Lymph Nodes; Lymphatic Metastasis; Neoplasm Staging; Ovarian Neoplasms; Prospective Studies; Sensitivity and Specificity; Sentinel Lymph Node; Sentinel Lymph Node BiopsySentinel lymph nodelaparoscopyCarcinoma Ovarian EpithelialSensitivity and SpecificityCohort Studiesindocyanine green (ICG)Ovarian EpithelialBiopsymedicineClinical endpointHumansProspective StudiesStage (cooking)Lymph nodeNeoplasm StagingOvarian Neoplasmsmedicine.diagnostic_testbusiness.industrySentinel Lymph Node BiopsyCarcinomaObstetrics and GynecologySentinel nodemedicine.diseaseearly ovarian cancer; indocyanine green (ICG); laparoscopy; lymphadenectomy; minimally-invasive surgery; sentinel nodeminimally-invasive surgerymedicine.anatomical_structureSettore MED/40 - GINECOLOGIA E OSTETRICIAOncologysentinel nodeLymphatic MetastasislymphadenectomyLymphadenectomyFemaleRadiologyLymph NodesSentinel Lymph NodebusinessOvarian cancer
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Application of a predictive model of axillary lymph node status in patients with sentinel node metastasis from breast cancer. A retrospective cohort …

2016

Abstract Background and objectives The Axillary Lymph Node Dissection (ALND) is the standard treatment in patients with invasive breast cancer and sentinel node metastasis, but in 60% of the cases there is no further axillary neoplastic involvement, so this invasive intervention represents an overtreatment. The purpose of the study is to identify patients with low risk of additional nodal metastases, to omit ALND. Methods The MSKCC Additional nodal metastasis nomogram was applied on a sample of 175 patients with invasive breast cancer who underwent ALND after detection of macrometastasis with the extemporaneous examination of the sentinel lymph node. Patients were classified as "low risk" w…

AdultOncologyAxilla; Breast neoplasms; Lymph node excision; Lymphatic metastasis; Sentinel lymph node biopsy; Surgerymedicine.medical_specialtySentinel lymph nodeBreast Neoplasms030230 surgeryRisk AssessmentSensitivity and SpecificityCohort Studies03 medical and health sciences0302 clinical medicineBreast cancerSentinel lymph node biopsyPositive predicative valueInternal medicinemedicineHumansMacrometastasisLymph nodeAgedRetrospective StudiesLymphatic metastasiAged 80 and overBreast neoplasmbusiness.industryAxillary Lymph Node DissectionGeneral MedicineMiddle AgedModels TheoreticalNomogramSentinel nodemedicine.diseaseNomogramsLymph node excisionmedicine.anatomical_structureROC CurveArea Under CurveLymphatic Metastasis030220 oncology & carcinogenesisAxillaFemaleSurgeryLymph NodesSentinel Lymph NodebusinessInternational Journal of Surgery
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Sentinel Node Identification in Melanoma: Current Clinical Impact, New Emerging SPECT Radiotracers and Technological Advancements. An Update of the L…

2020

Background: Melanoma is the most lethal skin cancer with a mortality rate of 262 cases per 100.000 cases. The sentinel lymph node (SLN) is the first lymph node draining the tumor. SLN biopsy is a widely accepted procedure in the clinical setting since it provides important prognostic information, which helps patient management, and avoids the side effects of complete lymph node dissection. The rationale of identifying and removing the SLN relies on the low probability of subsequent metastatic nodes in case of a negative histological exam performed in the SLN. Discussion: Recently, new analytical approaches, based on the evaluation of scintigraphic images are also exploring the possibility …

medicine.medical_specialtySingle Photon Emission Computed Tomography Computed TomographySkin NeoplasmsSentinel lymph nodeSingle-photon emission computed tomographySentinel lymph node biopsyhybrid imagingBiopsymedicineHumansRadiology Nuclear Medicine and imagingsentinel lymph node biopsyMelanomaLymph nodePharmacology99mTc-Tilmanoceptmedicine.diagnostic_testbusiness.industryMelanomaSPECT/CTSentinel nodePrognosismedicine.disease99mTc-colloids; 99mTc-Tilmanocept; Hybrid imaging; Melanoma; Sentinel lymph node biopsy; SPECT/CT; Humans; Lymphoscintigraphy; Melanoma; Prognosis; Radiopharmaceuticals; Sentinel Lymph Node; Single Photon Emission Computed Tomography Computed Tomography; Skin NeoplasmsDissectionHybrid imagingmedicine.anatomical_structure99mTc-colloidsRadiologyRadiopharmaceuticalsSentinel Lymph NodeSkin cancerbusinessLymphoscintigraphyCurrent Radiopharmaceuticals
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Lymphoscintigraphy with peritumoral injection versus lymphoscintigraphy with subdermal periareolar injection of technetium-labeled human albumin to i…

2014

Background Preoperative lymphoscintigraphy is without doubt a valid method for the detection of the sentinel lymph node (SLN). There has been considerable debate regarding the optimal site for the introduction of the tracer; various sites include peritumoral (PT), periareolar (PA), subdermal, and intradermal injection. Purpose To evaluate retrospectively the lymphoscintigraphic identification rate of peritumoral (PT) injection versus subdermal periareolar (PA) injection in the detection of SLNs in breast cancer. Material and Methods Between October 2002 and December 2011, a cohort of 906 consecutive patients with biopsy proven breast cancer underwent 914 SLN biopsy procedures. A total of 33…

Adultmedicine.medical_specialtySentinel lymph nodechemistry.chemical_elementBreast NeoplasmsInjections IntralesionalTechnetiumPeriareolarBreast cancerBiopsymedicineCarcinomaHumansRadiology Nuclear Medicine and imagingTechnetium Tc 99m Aggregated AlbuminAgedRetrospective StudiesAged 80 and overBreast cancer sentinel lymph node biopsy lymphoscintigraphy sub areolar peritumoral radio-colloidRadiological and Ultrasound Technologymedicine.diagnostic_testSentinel Lymph Node Biopsybusiness.industryHuman albuminGeneral MedicineMiddle AgedImage Enhancementmedicine.diseaseSurgerychemistryFemaleLymphRadiopharmaceuticalsSettore MED/36 - Diagnostica Per Immagini E RadioterapiaNuclear medicinebusinessLymphoscintigraphyActa Radiologica
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Can We Define the Risk of Lymph Node Metastasis in Early-Stage Cervical Cancer Patients? A Large-Scale, Retrospective Study

2017

BACKGROUND: Sentinel lymph node (SLN) biopsy has emerged as one of the most appreciated techniques for reducing the rate of complete lymph node dissection (LND) performed in patients with early-stage cervical cancer (ECC). However, its performances are still a matter of debate and, to improve them, international guidelines recommend performing at least unilateral LND in case of SLN mapping. In a prior study, we identified a group of patients without evidence of lymph node metastasis (LNM). Our objective is to define a precise risk of LNM for each ECC patient in order to significantly tailor surgery for ECC. METHODS: Clinical and pathological data of ECC patients were retrospectively collect…

AdultAdenocarcinoma; Adult; Aged; Aged 80 and over; Carcinoma Squamous Cell; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Middle Aged; Prognosis; Retrospective Studies; Risk Factors; Survival Rate; Uterine Cervical Neoplasms; Young Adult; Lymph Node Excision; Sentinel Lymph Node Biopsy0301 basic medicinemedicine.medical_specialtySentinel lymph nodeUterine Cervical NeoplasmsAdenocarcinomaLogistic regressionYoung Adult03 medical and health sciences0302 clinical medicineRisk FactorsmedicineHumansStage (cooking)Large-Scale Retrospective Study Sentinel lymph node (SLN) biopsy Lymphadenectomy (LND) early-stage cervical cancer (ECC)Lymph nodeAgedRetrospective StudiesAged 80 and overCervical cancerSentinel Lymph Node Biopsybusiness.industryRetrospective cohort studyMiddle AgedPrognosismedicine.diseaseSurgerySurvival Ratecervical cancer lymph nodes metastasesDissectionExact testSettore MED/40 - GINECOLOGIA E OSTETRICIA030104 developmental biologymedicine.anatomical_structureOncologyLymphatic Metastasis030220 oncology & carcinogenesisSurgery; OncologyCarcinoma Squamous CellLymph Node ExcisionFemaleSurgeryRadiologybusinessFollow-Up StudiesAnnals of Surgical Oncology
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The role of sentinel node tumor burden in modeling the prognosis of melanoma patients with positive sentinel node biopsy: an Italian melanoma intergr…

2022

Abstract Background: The management of melanoma patients with metastatic sentinel nodes (SN) is evolving based on the results of trials questioning the impact of completion lymph node dissection (CLND) and demonstrating the efficacy of new adjuvant treatments. In this landscape, new prognostic tools for fine risk stratification are eagerly sought to optimize the therapeutic path of these patients. Methods: A retrospective cohort of 2,086 patients treated with CLND after a positive SN biopsy in thirteen Italian Melanoma Centers was reviewed. Overall survival (OS) was the outcome of interest; included independent variables were the following: age, gender, primary melanoma site, Breslow thickn…

OncologyMaleTreatment of cutaneous melanomamedicine.medical_specialtyCompletion lymph node dissectionSkin NeoplasmsCLND; Completion lymph node dissection; Melanoma; Metastatic melanoma in the sentinel nodes; Nomogram; Overall survival; Prognostic factors; Risk stratification; Treatment of cutaneous melanoma; Tumor burden; Humans; Lymph Node Excision; Lymphatic Metastasis; Male; Prognosis; Retrospective Studies; Sentinel Lymph Node Biopsy; Tumor Burden; Lymphadenopathy; Melanoma; Sentinel Lymph Node; Skin NeoplasmsTumor burdenSettore MED/19 - Chirurgia PlasticaLymphadenopathyPrognostic factorsNomogramInternal medicineBiopsymedicineMetastatic melanoma in the sentinel nodesHumansCLNDOverall survivalMelanomaCLND; Completion lymph node dissection; Melanoma; Metastatic melanoma in the sentinel nodes; Nomogram; Overall survival; Prognostic factors; Risk stratification; Treatment of cutaneous melanoma; Tumor burdenRisk stratificationRetrospective Studiesmedicine.diagnostic_testbusiness.industrySentinel Lymph Node BiopsyMelanomaTumor burdenSentinel nodemedicine.diseasePrognosisLymphatic MetastasisLymph Node ExcisionSentinel Lymph Nodebusiness
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Breast cancer subtypes can be determinant in the decision making process to avoid surgical axillary staging: A retrospective cohort study.

2015

Abstract Introduction The need for performing axillary lymph-node dissection in early breast cancer when the sentinel lymph node (SLN) is positive has been questioned in recent years. The purpose of this study was to identify a low-risk subgroup of early breast cancer patients in whom surgical axillary staging could be avoided, and to assess the probability of having a positive lymph-node (LN). Methods We evaluated the cohort of 612 consecutive women affected by early breast cancer. We considered age, tumor size, histological grade, vascular invasion, lymphatic invasion and cancer subtype (Luminal A, Luminal B HER-2+, Luminal B HER-2−, HER-2+, and Triple Negative) as variables for univariat…

OncologyAdultmedicine.medical_specialtyLymphovascular invasionReceptor ErbB-2Sentinel lymph nodeClinical Decision-Makingbreast cancer axillary surgery sentinel lymph node biopsy adjuvant treatment biological prognostic factors.Breast NeoplasmsTriple Negative Breast NeoplasmsCohort StudiesBreast cancerInternal medicineMedicineHumansNeoplasm InvasivenessSettore SECS-S/05 - Statistica SocialeLymph nodeAgedNeoplasm StagingRetrospective StudiesGynecologyAged 80 and overbusiness.industrySentinel Lymph Node BiopsyAge FactorsCancerRetrospective cohort studyGeneral MedicineOdds ratioMiddle Agedmedicine.diseaseSettore MED/18 - Chirurgia GeneraleExact testmedicine.anatomical_structureLymphatic MetastasisAxillaLymph Node ExcisionSurgeryFemalebusinessInternational journal of surgery (London, England)
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Does Conservative Surgery for Breast Carcinoma Still Require Axillary Lymph Node Evaluation? A Retrospective Analysis of 1156 Consecutive Women With …

2016

Abstract Background The role of axillary surgery for early breast carcinoma treated with conservative surgery and radiotherapy is currently the subject of considerable investigation. Recent studies have supported the noninferiority of avoiding axillary surgery in terms of overall survival when sentinel lymph node biopsy (SLNB) presents ≤ 2 positive lymph nodes, thus sparing the patients from complications. There are some ongoing studies investigating the possibility of omitting SLNB. Axillary study seems to be sufficiently replaced by SLNB for staging the disease. Axillary surgery maintains a therapeutic role in the presence of > 2 metastatic lymph nodes at SLNB. Patients and Methods We per…

AdultT1 tumorsCancer Researchmedicine.medical_specialtymedicine.medical_treatmentSentinel lymph nodePopulationBreast Neoplasms030230 surgeryConservative Treatment03 medical and health sciences0302 clinical medicineBreast cancerAxillary lymph node dissectionmedicineHumansMore than two metastatic axillary lymph nodeeducationLymph nodeAgedNeoplasm StagingRetrospective StudiesAged 80 and overeducation.field_of_studybusiness.industrySentinel Lymph Node BiopsyAxillary Lymph Node DissectionAxillary lymph node dissection; More than two metastatic axillary lymph nodes; Not axillary surgery staging; Sentinel lymph node biopsy; T1 tumorsMiddle Agedmedicine.diseaseSurgeryRadiation therapymedicine.anatomical_structureOncology030220 oncology & carcinogenesisLymphatic MetastasisAxillaLymph Node ExcisionNot axillary surgery stagingFemaleRadiotherapy AdjuvantLymphSentinel Lymph NodeBreast carcinomabusinessClinical breast cancer
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